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Microphysiological Systems (MPS) is now a member of Committee on Publication Ethics (COPE)

Starting from July 2021, AME Publishing Company is formally recognized a publisher member of Committee on Publication Ethics (COPE) and over 60 AME-published journals become a member of Committee on Publication Ethics (COPE), as part of AME’s commitment to best practice in scholarly publishing. Microphysiological Systems (MPS) is among the list of COPE membership.

Microphysiological Systems in Drug development - Efficacy and Safety as Determined by Context of Use

This special series on “Microphysiological Systems in Drug development - Efficacy and Safety as Determined by Context of Use” is guest-edited by Dr. Dongeun (Dan) Huh from University of Pennsylvania and Dr. Yu Shrike Zhang from Harvard Medical School, and aims to reflect the updated overview of the most recent acquisitions and future perspectives.

Body-in-a-Cube: a microphysiological system for multi-tissue co-culture with near-physiological amounts of blood surrogate

Cell viability analysis showed that 95.5%±3.2% of liver cells, 89.8%±4.7% of bone marrow cells, 82.8%±8.1% of GI tract cells, and 80.1%±11.5% of kidney cells were viable in co-culture for 72 h. Both acetaminophen and troglitazone significantly lowered cell viability in the liver chamber as indicated by viability analysis and a temporary increase of AST in the cell culture medium. Both drugs also lowered ureaproduction in the liver by up to 45%.

Recent advancements of human iPSC derived cardiomyocytes in drug screening and tissue regeneration

This review presents an overview of various methods for improving the differentiation efficiency of hiPSC-CMs and discuss the differences of electrophysiological characteristics between hiPSC-CMs and matured native CMs. It also introduces approaches for obtaining a large quantity of iPSC-CMs, which are needed to achieve biomanufacturing strategies for building biomimetic three-dimensional tissue constructs using combinations of biomaterials and advanced microfabrication techniques.

SARS-CoV-2-related vascular injury: mechanisms, imaging and models

This concise editorial provides an overall account of the cellular mechanisms currently thought to contribute to vascular pathology in patients with COVID-19. It also discusses the various vascular diseases involved in the COVID-19 clinical course. Finally, it explores the use of emerging imaging technologies in conjunction with models of tissue injury to better visualize and understand SARS-CoV-2-driven vascular damage.

Microphysiological Systems

It has been increasingly realized that the conventional planar cell cultures and the animals do not necessarily reproduce human physiology in vitro due to their limited structural and functional complexity and the genetic difference, respectively, oftentimes leading to inaccurate prediction of drug, chemical, and toxin effects as well as biased outcomes of biological investigations. Miniaturized physiological systems are therefore proposed as alternative platforms that are anticipated to bridge the gap between currently available models and the human body. The Journal Microphysiological Systems (Microphysiol Syst; MPS) aims to provide latest insights and updates on the developments of in vitro tissue and organ models that can be used for applications ranging from biological studies to areas such as regenerative engineering, organs-on-chips, pharmaceutical screening, nanomedicine, and environmental toxicology.

Editor-in-Chief: Yu Shrike Zhang, PhD

Dr. Zhang received his Ph.D. in Biomedical Engineering from Georgia Institute of Technology (2013), M.S. in Biomedical Engineering from Washington University in St. Louis (2011), and B.Eng. in Biomedical Engineering at Southeast University in China (2008). He is currently an Instructor of Medicine and Associate Bioengineer at Brigham and Women’s Hospital and Harvard Medical School. Dr. Zhang has a broad background in biomedical engineering, where his research is based on the investigation of multi-scale biomaterials and biotechnologies to develop functional tissues and organ models and their use in translational therapeutics. In particular, he is highly experienced in research areas related with biomedical and medical devices such as organs-on-chip, biosensing, and imaging, as well as 3D bioprinting, biomaterials, tissue engineering, and drug and cell delivery.

Associate Editor-in-Chief: Dongeun (Dan) Huh, PhD

Huh's laboratory aims to develop innovative bioengineering tools and technologies using biologically inspired design principles and micro/nanoengineering approaches to improve human health and promote environmental sustainability. Huh's research focuses primarily on developing i) microengineered biomimetic models of human organs (organs-on-chips), ii) self-assembled tissue/organ scaffolds, iii) cell-based self-regulating "smart" biomedical devices, and iv) efficient biomimetic transport systems. The laboratory explores the use of these bioinspired engineering systems for a variety of biomedical, pharmaceutical, and environmental applications.

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Erratum

Erratum to Body-in-a-Cube: a microphysiological system for multi-tissue co-culture with near-physiological amounts of blood surrogate

Editorial Office

Microphysiological Systems

2021;

(26 June 2021)

PDF Full Text (1566) Open Access

Editorial

SARS-CoV-2-related vascular injury: mechanisms, imaging and models

Lucas Humayun, Colin Smith, Wanlu Li, Yu Shrike Zhang, Christine Park, Wuwei Feng, Junjie Yao

Microphysiological Systems

2021;

(26 January 2021)

PDF Full Text (3166) COI Form Open Access

Review Article

Recent advancements of human iPSC derived cardiomyocytes in drug screening and tissue regeneration

Yike Huang, Ting Wang, María Elizabeth Urbina López, Minoru Hirano, Anwarul Hasan, Su Ryon Shin

Microphysiological Systems

2020;

(15 September 2020)

PDF Full Text (4860) COI Form Open Access

Review Article

Body-in-a-Cube: a microphysiological system for multi-tissue co-culture with near-physiological amounts of blood surrogate

Longyi Chen, Yang Yang, Hidetaka Ueno, Mandy B. Esch

Microphysiological Systems

2020;

(08 June 2020)

PDF Full Text (5099) COI Form Open Access

Review Article

Fiber-based microphysiological systems: a powerful tool for high throughput drug screening

Tavia Walsh, Lucas Karperien, Seyed Mohammad Hossein Dabiri, Mohsen Akbari

Microphysiological Systems

2019;

(17 September 2019)

PDF Full Text (3515) COI Form Open Access

Editorial

Engineering bone marrow-on-a-chip

Yu-suke Torisawa

Microphysiological Systems

2019;

(12 March 2019)

PDF Full Text (4094) COI Form Open Access

Editorial

Organs-on-chips: latest developments

Andries D. van der Meer

Microphysiological Systems

2019;

(04 January 2019)

PDF Full Text (7174) COI Form Open Access

Progress Report

Microphysiological systems to study microenvironment-cell nucleus interaction: importance of tissue geometry and heterogeneity

Sophie A. Lelièvre, Shirisha Chittiboyina

Microphysiological Systems

2018;

(11 December 2018)

PDF Full Text (3884) COI Form Open Access

Review Article

Microsystems for electromechanical stimulations to engineered cardiac tissues

Samantha M. Santoni, Tackla Winston, Plansky Hoang, Zhen Ma

Microphysiological Systems

2018;

(06 December 2018)

PDF Full Text (5284) COI Form Open Access

Mini-Review

Microphysiological systems: analysis of the current status, challenges and commercial future

João Ribas, Joanna Pawlikowska, Jeroen Rouwkema

Microphysiological Systems

2018;

(05 November 2018)

PDF Full Text (9203) COI Form Open Access

Review Article

3D bioprinting for modelling vasculature

Pranabesh Sasmal, Pallab Datta, Yang Wu, Ibrahim T. Ozbolat

Microphysiological Systems

2018;

(05 November 2018)

PDF Full Text (10090) COI Form Open Access

Review Article

Recent organ-on-a-chip advances toward drug toxicity testing

Jiu Deng, Yueyang Qu, Tingjiao Liu, Bolin Jing, Xiuli Zhang, Zongzheng Chen, Yong Luo, Weijie Zhao, Yao Lu, Bingcheng Lin

Microphysiological Systems

2018;

(25 October 2018)

PDF Full Text (6994) COI Form Open Access

Review Article

Gut-microbiota-on-a-chip: an enabling field for physiological research

Grissel Trujillo-de Santiago, Matías José Lobo-Zegers, Silvia Lorena Montes-Fonseca, Yu Shrike Zhang, Mario Moisés Alvarez

Microphysiological Systems

2018;

(16 October 2018)

PDF Full Text (14957) COI Form Open Access

Progress Report

Recent progresses in microfabricating perfluorinated polymers (Teflons) and the associated new applications in microfluidics

Yisu Wang, Siyu Chen, Han Sun, Wanbo Li, Chong Hu, Kangning Ren

Microphysiological Systems

2018;

(28 September 2018)

PDF Full Text (6628) COI Form Open Access

Review Article

Organs-on-chip monitoring: sensors and other strategies

Tugba Kilic, Fatemeh Navaee, Francesca Stradolini, Philippe Renaud, Sandro Carrara

Microphysiological Systems

2018;

(05 September 2018)

PDF Full Text (22261) COI Form Open Access

Review Article

Current advances in skin-on-a-chip models for drug testing

Qiang Zhang, Linda Sito, Mao Mao, Jiankang He, Yu Shrike Zhang, Xin Zhao

Microphysiological Systems

2018;

(30 August 2018)

PDF Full Text (13822) COI Form Open Access

Review Article

Integrating mass spectrometry with microphysiological systems for improved neurochemical studies

Emily G. Tillmaand, Jonathan V. Sweedler

Microphysiological Systems

2018;

(11 June 2018)

PDF Full Text (4612) COI Form Open Access

Review Article

Microphysiological Systems: automated fabrication via extrusion bioprinting

Margaret Elizabeth Prendergast, Gabriel Montoya, Taciana Pereira, Jakub Lewicki, Ricky Solorzano, Anthony Atala

Microphysiological Systems

2018;

(22 March 2018)

PDF Full Text (7804) COI Form Open Access

Review Article

DNA mediated self-assembly of multicellular microtissues

Mingshu Xiao, Wei Lai, Xiwei Wang, Xiangmeng Qu, Li Li, Hao Pei

Microphysiological Systems

2018;

(09 January 2018)

PDF Full Text (6061) COI Form Open Access

Editorial

Flushing out the scattering: fast on-chip microfluidic clearing of microtissues

Junjie Yao

Microphysiological Systems

2017;

(09 November 2017)

PDF Full Text (4297) COI Form Open Access

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Review Article

Organs-on-chip monitoring: sensors and other strategies

Tugba Kilic, Fatemeh Navaee, Francesca Stradolini, Philippe Renaud, Sandro Carrara

Published online: 05 September 2018

PDF Full Text (22261) COI Form Open Access

Review Article

Gut-microbiota-on-a-chip: an enabling field for physiological research

Grissel Trujillo-de Santiago, Matías José Lobo-Zegers, Silvia Lorena Montes-Fonseca, Yu Shrike Zhang, Mario Moisés Alvarez

Published online: 16 October 2018

PDF Full Text (14957) COI Form Open Access

Review Article

Current advances in skin-on-a-chip models for drug testing

Qiang Zhang, Linda Sito, Mao Mao, Jiankang He, Yu Shrike Zhang, Xin Zhao

Published online: 30 August 2018

PDF Full Text (13822) COI Form Open Access

Review Article

3D bioprinting for modelling vasculature

Pranabesh Sasmal, Pallab Datta, Yang Wu, Ibrahim T. Ozbolat

Published online: 05 November 2018

PDF Full Text (10090) COI Form Open Access

Mini-Review

Microphysiological systems: analysis of the current status, challenges and commercial future

João Ribas, Joanna Pawlikowska, Jeroen Rouwkema

Published online: 05 November 2018

PDF Full Text (9203) COI Form Open Access

Review Article

Microphysiological Systems: automated fabrication via extrusion bioprinting

Margaret Elizabeth Prendergast, Gabriel Montoya, Taciana Pereira, Jakub Lewicki, Ricky Solorzano, Anthony Atala

Published online: 22 March 2018

PDF Full Text (7804) COI Form Open Access

Editorial

Organs-on-chips: latest developments

Andries D. van der Meer

Published online: 04 January 2019

PDF Full Text (7174) COI Form Open Access

Review Article

Recent organ-on-a-chip advances toward drug toxicity testing

Jiu Deng, Yueyang Qu, Tingjiao Liu, Bolin Jing, Xiuli Zhang, Zongzheng Chen, Yong Luo, Weijie Zhao, Yao Lu, Bingcheng Lin

Published online: 25 October 2018

PDF Full Text (6994) COI Form Open Access

Progress Report

Recent progresses in microfabricating perfluorinated polymers (Teflons) and the associated new applications in microfluidics

Yisu Wang, Siyu Chen, Han Sun, Wanbo Li, Chong Hu, Kangning Ren

Published online: 28 September 2018

PDF Full Text (6628) COI Form Open Access

Review Article

Prospects and challenges in engineering functional respiratory epithelium for in vitro and in vivo applications

Pramod Kumar, Nihal E. Vrana, Amir M. Ghaemmaghami

Published online: 18 October 2017

PDF Full Text (6344) COI Form Open Access

Review Article

DNA mediated self-assembly of multicellular microtissues

Mingshu Xiao, Wei Lai, Xiwei Wang, Xiangmeng Qu, Li Li, Hao Pei

Published online: 09 January 2018

PDF Full Text (6061) COI Form Open Access

Review Article

Microsystems for electromechanical stimulations to engineered cardiac tissues

Samantha M. Santoni, Tackla Winston, Plansky Hoang, Zhen Ma

Published online: 06 December 2018

PDF Full Text (5284) COI Form Open Access

Review Article

Body-in-a-Cube: a microphysiological system for multi-tissue co-culture with near-physiological amounts of blood surrogate

Longyi Chen, Yang Yang, Hidetaka Ueno, Mandy B. Esch

Published online: 08 June 2020

PDF Full Text (5099) COI Form Open Access

Review Article

Recent advancements of human iPSC derived cardiomyocytes in drug screening and tissue regeneration

Yike Huang, Ting Wang, María Elizabeth Urbina López, Minoru Hirano, Anwarul Hasan, Su Ryon Shin

Published online: 15 September 2020

PDF Full Text (4860) COI Form Open Access

Review Article

Integrating mass spectrometry with microphysiological systems for improved neurochemical studies

Emily G. Tillmaand, Jonathan V. Sweedler

Published online: 11 June 2018

PDF Full Text (4612) COI Form Open Access

Editorial

Flushing out the scattering: fast on-chip microfluidic clearing of microtissues

Junjie Yao

Published online: 09 November 2017

PDF Full Text (4297) COI Form Open Access

Editorial

Engineering bone marrow-on-a-chip

Yu-suke Torisawa

Published online: 12 March 2019

PDF Full Text (4094) COI Form Open Access

Progress Report

Microphysiological systems to study microenvironment-cell nucleus interaction: importance of tissue geometry and heterogeneity

Sophie A. Lelièvre, Shirisha Chittiboyina

Published online: 11 December 2018

PDF Full Text (3884) COI Form Open Access

Review Article

Fiber-based microphysiological systems: a powerful tool for high throughput drug screening

Tavia Walsh, Lucas Karperien, Seyed Mohammad Hossein Dabiri, Mohsen Akbari

Published online: 17 September 2019

PDF Full Text (3515) COI Form Open Access

Editorial

SARS-CoV-2-related vascular injury: mechanisms, imaging and models

Lucas Humayun, Colin Smith, Wanlu Li, Yu Shrike Zhang, Christine Park, Wuwei Feng, Junjie Yao

Published online: 26 January 2021

PDF Full Text (3166) COI Form Open Access

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Review Article

3D bioprinting for modelling vasculature

Pranabesh Sasmal, Pallab Datta, Yang Wu, Ibrahim T. Ozbolat

Review Article

Integrating mass spectrometry with microphysiological systems for improved neurochemical studies

Emily G. Tillmaand, Jonathan V. Sweedler

Journal Highlight more

Microphysiological Systems aims to provide latest insights and updates on the developments of in vitro tissue and organ models that can be used for applications ranging from biological studies to areas such as regenerative engineering, organs-on-chips, pharmaceutical screening, nanomedicine, and environmental toxicology.